Cannabidiol reduces LPS-induced inflammatory response in the human placenta by reducing NF-κB translocation.

ABSTRACT:

Background

Cannabidiol (CBD), a non-psychoactive cannabinoid increasingly used during pregnancy, has been proposed to modulate inflammatory processes. However, its effects on human placental immune functions remain poorly characterized. This study investigates the impact of CBD on lipopolysaccharide (LPS)-induced inflammation in human placenta explants and primary trophoblast cells, focusing on cytokine expression, receptor involvement, and underlying mechanisms.

Methods

Term placental explants and syncytiotrophoblast cells were exposed to LPS with or without CBD. Inflammatory cytokine levels were quantified by ELISA and RT-qPCR. Receptor involvement was assessed using selective antagonists for cannabinoid receptors type 1 and 2 (CB1 and CB2), and transient receptor potentia

SUBMITTER: Portillo R 

PROVIDER: S-EPMC12797442 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature