Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial.

ABSTRACT:

Background

Intracerebral hemorrhage (ICH) is a challenging and life-threatening stroke subtype. Normobaric hyperoxia (NBO) is a promising therapeutic strategy for ICH. Herein, we evaluated the safety and efficacy of NBO in patients with ICH.

Methods

In this randomized, controlled, two-arm (1:1 ratio), open-label clinical trial, participants were randomly assigned to either the NBO group (100% O₂ at 8 L/min for 1 h per session, four times daily, for 7 days) or the control group (100% O₂ at 2 L/min continuously for 24 h daily for 7 days). The primary outcome was the proportion of patients achieving a modified Rankin Scale (mRS) score of 0-3 at 90 days. The results are presented as the risk ratio (RR) with 95% confidence intervals (95% CI). P < .05 indicat

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12797582 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature