Nationwide trends and disparities in deaths following cardiogenic shock and sepsis in the United States (1999-2023): insights from the CDC WONDER database.

ABSTRACT:

Background

Cardiogenic shock (CS) with sepsis is a highly fatal condition, yet national mortality trends and demographic disparities in these co-occurring conditions remain poorly characterized.

Methods

We analyzed CDC WONDER Multiple Cause of Death data (1999-2023) to identify adult deaths involving both CS and sepsis. Age-adjusted mortality rates (AAMRs), crude mortality rates (CMRs), average annual percent change (AAPC), and annual percent change (APC) by period were calculated and stratified by sex, race, age, census region, urbanization, and state.

Results

From 1999 to 2023, 59,898 deaths were recorded, overwhelmingly in inpatient medical facilities (94.61%). The national AAMR rose from 0.65 (1999) to 2.01 (2023), with an overall AAPC of 5.39 (95% CI: 4.24-6.56,

SUBMITTER: Zeeshan N 

PROVIDER: S-EPMC12797607 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature