Polygenic risk for schizophrenia predicting test-measured and self-reported cognitive performance in individuals without psychosis.

ABSTRACT:

Introduction

Schizophrenia is characterized by weaker test-measured cognitive performance, which is partially explained by disease-related secondary factors (after the onset of the disorder) such as side effects of antipsychotics, stigma, or sedentary behavior. We examined whether polygenic risk for schizophrenia (PRSSCZ) is associated with (a) test-measured or (b) self-reported cognitive performance in individuals who have not converted into non-affective psychosis during follow-up to extending to middle age.

Methods

The participants came from the population-based Young Finns Study, born between 1962 and 1977 (n = 2217). Participants with diagnosed non-affective psychoses were excluded from the sample. Diagnoses collected from the Care Register for Health Care. PRS_SCZ<

SUBMITTER: Rosenqvist E 

PROVIDER: S-EPMC12797622 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature