Phage therapy in revision arthroplasty: State of the art and application protocols.

ABSTRACT:

Introduction

Periprosthetic joint infections (PJI) pose significant clinical challenges due to biofilm formation and antibiotic resistance. Standard treatment often involves implant removal and prolonged antibiotic therapy. Novel strategies target intracellular pathogens and biofilm-associated bacteria, including liposomal antibiotics, antimicrobial peptides, and bacteriophage therapy. Bacteriophages offer specificity and minimal disruption to human microbiota but remain experimental in PJI. Combining phages with targeted antibiotics shows promising results in preclinical models, though further research is needed to confirm efficacy in human PJI and optimise delivery methods.

Objectives

This study updates the current evidence on the use of bacteriophages for patients with PJ

SUBMITTER: Wolfgart JM 

PROVIDER: S-EPMC12797624 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature