Using single-cell and transcriptome data to identify prognostic genes associated with SUMO-ylation and their molecular regulatory mechanisms in breast cancer.

ABSTRACT:

Background

Dysregulation of small ubiquitin-like modifier ylation (SUMO-ylation) is closely associated with the development of different types of cancers. Growing evidence indicates that many SUMOylated genes (SRGs) play a role in the initiation and progression of breast cancer (BRCA). However, its prognostic value in BRCA remains inadequately explored.

Methods

This study explored prognostic genes related to SUMO-ylation in BRCA based on single-cell RNA sequencing (scRNA-seq) and transcriptome data, developed and validated a risk model. Furthermore, an analysis of clinical relevance was performed to determine independent prognostic factors associated with BRCA. Additionally, enrichment analysis, immune analysis, drug sensitivity analysis, and construction of molecular regula

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12797648 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature