Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.

ABSTRACT:

Background

Cyclin B2 (CCNB2), a member of the cyclin family, plays a crucial role in glycolysis and the progression of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modifications, particularly histone lactylation, have emerged as novel markers associated with glycolysis. However, the specific mechanisms by which CCNB2 influences histone lactylation in PDAC remain unclear.

Methods

We investigated the involvement of CCNB2 in PDAC growth and progression using glycolysis inhibitors in vivo and in vitro. The expression levels of CCNB2 in PDAC were assessed through bioinformatics analysis, Western blotting, and immunohistochemistry. Additionally, we analyzed the correlation between CCNB2 expression and patient prognosis using online databases. By manipulating

SUBMITTER: Ma B 

PROVIDER: S-EPMC12797688 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature