MARTS-DB: a database of mechanisms and reactions of terpene synthases.

ABSTRACT:

Background

Terpene synthases (TPSs) are enzymes that catalyze some of the most complex reactions in nature-the cyclizations of terpenes, which form the carbon backbones to the largest group of natural products, the terpenoids. On average, more than half of the carbon atoms in a terpene scaffold undergo a change in connectivity or configuration during these enzymatic cascades. Understanding TPS reaction mechanisms remains challenging, often requiring intricate computational modeling and isotopic labelling studies. Moreover, the relationship between TPS sequence and catalytic function is difficult to decipher, while data-driven approaches remain limited due to a lack of comprehensive, high-quality data sources. MAIN: We introduce the Mechanisms And Reactions of Terpene Synthases Data

SUBMITTER: Engst M 

PROVIDER: S-EPMC12797696 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature