Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.

ABSTRACT: Coarctation of the aorta (CoA) is a common congenital cardiovascular lesion that presents as a localized narrowing of the proximal descending aorta. While improvements in surgical and catheter-based techniques have increased short-term survival, there is a high long-term risk of hypertension and a reduced average lifespan despite correction. Computational models can be used to estimate aortic remodeling and peripheral vascular compensation, potentially serving as key tools in developing a mechanistic understanding of the interplay between pre-treatment dynamics, post-treatment recovery, and long-term hypertension risk. In this study, we developed a lumped-parameter model of the heart and circulation to simulate CoA. After fitting model parameters using imaging and catheterization data from

SUBMITTER: Hiebing AA 

PROVIDER: S-EPMC12797878 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature