Remimazolam compared to dexmedetomidine on the incidence of hypotension in middle aged and elderly patients undergoing general anesthesia: a systematic review and meta-analysis.

ABSTRACT:

Background

The objective of this study is to compare the effects of remimazolam and dexmedetomidine on the incidence of hypotension in middle-aged and elderly patients undergoing general anesthesia, and to evaluate the safety profiles of both medications.

Methods

We systematically searched PubMed, Cochrane Library, EMBASE, and Web of Science from inception to July 2024 for randomized controlled trials comparing remimazolam versus dexmedetomidine in patients aged ≥ 45 years undergoing general anesthesia. Two investigators independently screened studies, extracted data, and assessed risk of bias using the Cochrane RoB 2 tool. Meta-analyses employed random-effects models to calculate risk ratios (RR) with 95% confidence intervals. The primary outcome was intraoperative hypotens

SUBMITTER: Wang M 

PROVIDER: S-EPMC12797900 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature