CircRNF10 sequestrates β-catenin by a dual regulatory circuit of direct degradation and a miR-1275/DKK3-mediated inhibition in driver gene- negative lung adenocarcinoma.

ABSTRACT:

Background

Circular RNAs (circRNAs) exert critical regulatory functions in tumor biology by modulating pathways associated with oncogenesis or tumor suppression. Despite substantial progress in elucidating their roles in several malignancies, the contribution of circRNAs to the pathogenesis of driver gene-negative lung adenocarcinoma (LUAD), a molecular subtype lacking actionable genetic alterations and exhibiting limited response to existing targeted or immunotherapeutic strategies, remains poorly defined.

Methods

The expression of circRNF10 in driver gene-negative LUAD was analyzed using circRNA microarray analysis followed by RT-qPCR validation. A series of functional assays were performed both in vitro and in vivo to evaluate the effects of circRNF10 on tumor cell behavi

SUBMITTER: Situ X 

PROVIDER: S-EPMC12797959 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature