Temporal trends and disparities in cardiovascular disease-related mortality among adults with multiple myeloma in the United States, 1999-2023.

ABSTRACT:

Background

Novel therapeutic agents have substantially improved multiple myeloma (MM) survival, making cardiovascular disease (CVD) a predominant cause of non-cancer mortality. Because MM predominantly affects older adults (median age 69 years) at elevated cardiovascular risk, we focused on adults aged ≥ 45 years. Comprehensive national data on temporal trends and demographic disparities in CVD-related mortality among MM patients remain limited.

Methods

We conducted a retrospective analysis using CDC WONDER Multiple Cause-of-Death database data (1999-2023) for U.S. adults aged ≥ 45 years with MM and CVD as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) per 100,000 population were standardized to the 2000 U.S. standard population using the di

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12798013 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature