A prognostic model based on immune cells in tumor microenvironment to predict prognosis in endometrial cancer.

ABSTRACT:

Objective

The interaction between the tumor immune microenvironment (TIME) and malignant tumor cells plays a crucial role in tumor initiation and progression. This study aimed to establish and validate a prognostic model based on TIME characteristics to predict prognosis and guide personalized treatment in patients with endometrial cancer (EC).

Methods

A total of 67 EC patients who underwent surgery and TIME profiling at Peking University People's Hospital between January 2018 and December 2022 were included in this study. A prognostic model was developed based on the densities of stroma CD3⁺cell and stroma CD8⁺cells. To validate the model, an independent cohort of 200 EC patients was used, in which immunohistochemical (IHC) staining for CD3⁺

SUBMITTER: Li L 

PROVIDER: S-EPMC12798028 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature