Diagnostic performance of procalcitonin and presepsin in sepsis: a systematic review and meta-analysis.

ABSTRACT:

Background

Sepsis is a critical emergency condition characterized by life-threatening organ dysfunction due to a dysregulated response to infection. In the fast-paced emergency department (ED) setting, rapid identification and prompt initiation of treatment within the initial hours following sepsis onset are critical for reducing mortality and improving patient outcomes. However, a timely and accurate diagnosis remains a significant challenge in emergency medicine. Biomarkers such as procalcitonin (PCT) and presepsin (P-SEP) have been proposed as tools to distinguish sepsis from other non-infectious inflammatory conditions frequently encountered in the ED, though their diagnostic effectiveness remains controversial. This study aimed to evaluate the diagnostic performance of PCT and

SUBMITTER: Chairaj T 

PROVIDER: S-EPMC12798056 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature