Effect of grafting site on reproductive outcomes following cryopreserved ovarian tissue transplantation: a meta-analysis and systematic review.

ABSTRACT:

Background

More than 500 patients have received cryopreserved ovarian tissue transplantation (OTT) worldwide, resulting in over 200 live births. Although guidelines recognize OTT as an effective fertility preservation method, there is no consensus on the optimal grafting site of OTT. This systematic review and meta-analysis aim to assess whether reproductive outcomes of OTT vary across different grafting sites.

Methods

A literature search was conducted through March, 2024, in PubMed, Embase and the Cochrane library, using the following terms: 'patient', 'fertility preservation', 'ovarian tissue transplantation' and 'live birth'. Studies including 5 or more subjects were included. Two reviewers independently selected the studies, collected the data and assessed the risk of bi

SUBMITTER: Li Z 

PROVIDER: S-EPMC12798061 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature