LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis.

ABSTRACT:

Background

Ischemic stroke is a leading cause of morbidity and mortality worldwide, yet available therapeutic strategies remain limited. La ribonucleoprotein domain family member 7 (LARP7), a critical regulator of RNA stability and transcriptional control, participates in cellular stress responses and inflammatory modulation. Emerging evidence suggests LARP7's involvement in neuroinflammation and neuronal survival, yet its role in ischemic stroke pathogenesis is still poorly understood.

Methods

We systematically investigated LARP7 expression in patients with acute ischemic stroke (AIS), mice subjected to middle cerebral artery occlusion/reperfusion (MCAO/R), and neurons exposed to oxygen-glucose deprivation/reoxygenation (OGD/R). To elucidate the role of LARP7 in ischemic st

SUBMITTER: Tang H 

PROVIDER: S-EPMC12798097 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature