Prospective evaluation of 2nd generation rapid diagnostic tests for the serological diagnosis of gambiense human African trypanosomiasis in the Democratic Republic of the Congo.

ABSTRACT:

Background

Accurate diagnosis is essential for achieving the 2030 goal of eliminating gambiense human African trypanosomiasis (gHAT) transmission. In recent years, novel screening and confirmatory laboratory tests, including rapid diagnostic tests incorporating recombinant antigens (2nd generation RDTs), an inhibition ELISA (iELISA) and RT-qPCR, have been developed. However, data on their diagnostic performance remain limited. This study aimed to evaluate the specificity of these newly developed tests, with particular emphasis on 2nd generation RDTs.

Methods

During routine mobile team screening rounds in the Democratic Republic of the Congo, all consenting individuals aged ≥ 12 years provided a venous blood sample to screen for gHAT by Card Agglutination Test for Trypanosomi

SUBMITTER: Tablado Alonso S 

PROVIDER: S-EPMC12798099 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature