RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR.

ABSTRACT:

Background

RAB40C, a member of the Ras oncogene family, is an important regulator in cell signal transduction, cell growth and differentiation. Studies imply that it is a potentially pernicious factor in cancers, however, the correlation between RAB40C and hepatocellular carcinoma (HCC) progression is still not explored.

Methods

RAB40C expression and its clinical significance in HCC were analyzed using the Cancer Genome Atlas (TCGA) databases. The gene expression in liver tumor tissues was detected by western blot and quantitative real-time PCR. The effects of RAB40C in vitro and in vivo were evaluated by CCK8, colony formation, transwell assays and tumor xenograft. Mass spectrometry analysis, co-immunoprecipitation assay, ubiquitination modification was applied to revealed

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12798101 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature