CMEO: a metadata-centric ontology for clinical studies exploration and harmonization assessment.

ABSTRACT: The integration of clinical research data across various institutions faces hurdles due to differing definitions, inconsistent terminologies, and inadequate support for interoperable metadata. While biomedical ontologies offer valuable tools for structuring clinical data, they have not yet been fully utilized for creating comprehensive metadata descriptors, such as variable semantics, statistical summaries, and governance elements essential for data discovery and alignment. We present the Clinical Metadata Exploration Ontology (CMEO) that builds upon well-established ontologies to provide a cohesive representation of study designs, data elements, exploratory statistics, and data reuse permissions. CMEO facilitates semantic querying for study exploration and comparison of data elements acro

SUBMITTER: Gilani K 

PROVIDER: S-EPMC12798102 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature