Prognostic nutritional index and the survival of patients with hepatocellular carcinoma on immune checkpoint inhibitors: a meta-analysis.

ABSTRACT:

Background

The prognostic nutritional index (PNI), reflecting both nutritional and immune status, may be associated with survival in hepatocellular carcinoma (HCC) patients treated with immune checkpoint inhibitors (ICIs). However, findings across individual studies remain inconsistent. This meta-analysis aimed to assess the association between pretreatment PNI and survival outcomes in HCC patients receiving ICIs.

Methods

A systematic search of PubMed, Embase, and Web of Science was conducted from inception to May 31, 2025. Cohort studies reporting hazard ratios (HRs) for overall survival (OS) and/or progression-free survival (PFS) by baseline PNI levels in HCC patients on ICIs were included. Pooled HRs with 95% confidence intervals (CIs) were calculated using random-effects

SUBMITTER: Fu J 

PROVIDER: S-EPMC12798109 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature