Clinical Effects and Safety Outcomes of Platelet-Rich Plasma Therapy in Patients with Vasculogenic Erectile Dysfunction: A Systematic Review and Meta-Analysis.

ABSTRACT:

Purpose

Erectile dysfunction (ED) significantly impacts quality of life and intimate relationships. ED results from a complex interaction of physiological, psychological, and lifestyle factors. While conventional treatments focus on symptom management, regenerative therapies like platelet-rich plasma (PRP) aim to address underlying causes, offering curative potential. However, evidence for PRP's efficacy in vasculogenic ED remains inconclusive. This systematic review and meta-analysis (SRMA) evaluates the effectiveness of penile PRP injections for vasculogenic ED and updates clinical guidelines based on recent evidence.

Materials and methods

Conducted per MOOSE guidelines and registered with PROSPERO (CRD42023430295), this SRMA included observational studies and randomized c

SUBMITTER: Falcone M 

PROVIDER: S-EPMC12798389 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature