Intermedin prevents acute heart failure following acute kidney injury by alleviating inflammatory responses.

ABSTRACT: Acute heart failure (AHF) is a common complication of acute kidney injury (AKI), which leads to a poor prognosis in AKI patients. The pathogenesis of AHF is closely related to cardiac inflammatory responses. Intermedin (IMD) has been demonstrated to attenuate cardiac inflammation, however, its role in AHF following AKI (AKI-AHF) remains to be elucidated. We aimed to investigate the effects of IMD on AKI-AHF and to elucidate the underlying mechanisms. We demonstrated that AKI induced by bilateral kidney ischemia-reperfusion injury (IRI) upregulated IMD and its receptors in the kidneys and heart. Following kidney IRI, AHF was more severe in IMD knockout (IMD^-/-) mice compared with wild-type littermates, indicating IMD attenuates AKI-AHF. To clarify whether IMD has a direct effect

SUBMITTER: He Y 

PROVIDER: S-EPMC12798669 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature