Changing microbiology and outcomes of PD-associated peritonitis over four decades.

ABSTRACT:

Background

Peritoneal dialysis (PD)-associated peritonitis remains a major complication affecting patient outcomes and modality survival. This study aims to evaluate temporal trends in pathogen distribution and antibiotic susceptibility over four decades as well as clinical outcomes in PD-associated peritonitis.

Methods

We retrospectively analyzed 832 peritonitis cultures of PD patients across four decades from 1979 to 2024 treated at Robert Bosch Hospital, Stuttgart (Germany). For longitudinal comparison of pathogen distribution and antibiotic susceptibility, the study period was divided into four time periods: P1 (1979-1992), P2 (1993-2003), P3 (2004-2014), and P4 (2015-2024). Clinical response and outcomes were assessed in P4.

Results

Gram-positive bacteria was the

SUBMITTER: Kraft L 

PROVIDER: S-EPMC12798722 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature