Ultrasound-Activated Biodegradable Piezoelectric Chitosan Nanoparticles for Glioblastoma Treatment.

ABSTRACT: Piezoelectric nanomaterials are highly promising for remote cell stimulation due to their ability to convert mechanical energy, such as ultrasound (US), into electrical cues that modulate cellular behavior. In the context of cancer treatment, piezoelectric stimulation has recently shown antiproliferative, chemosensitizing, antiangiogenic, and immunomodulatory effects. Despite growing interest in organic alternatives, no biodegradable or bioabsorbable nanoparticles with clinically approved components have yet been developed with piezoelectric properties for cell stimulation, limiting the translational potential of this approach. Here, chitosan nanoparticles (ChNPs) have been engineered to exhibit intrinsic piezoelectric properties, enabling US-mediated activation. Their structural, mechanic

SUBMITTER: Marino A 

PROVIDER: S-EPMC12798788 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature