Assessment of cumulative health risk in the World Trade Center general responder cohort.

ABSTRACT:

Background

Multiple comorbidities have been reported among rescue/recovery workers responding to the 9/11/2001 WTC disaster. In this study, we developed an index that quantifies the cumulative physiological burden of comorbidities and predicts life expectancy in this cohort.

Methods

A machine learning approach (gradient boosting) was used to model the relationship between mortality and several clinical parameters (laboratory test results, blood pressure, pulmonary function measures). This model was used to construct a risk index, which was validated by assessing its association with a number of health outcomes within the WTC general responder cohort.

Results

The risk index showed significant associations with mortality, self-assessed physical health, and onset of mult

SUBMITTER: Bello GA 

PROVIDER: S-EPMC12798799 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature