Diagnostic Potential of Cerebrospinal Fluid Biomarkers in Diagnosis of Primary Central Nervous System Lymphoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Primary central nervous system lymphoma (PCNSL) is an aggressive form of non-Hodgkin's lymphoma primarily restricted to the brain, spinal cord, eyes, and leptomeninges without any evidence of systemic spread. It is often challenging to diagnose PCNSL due to its clinical and radiological overlap with various central nervous system (CNS) inflammatory conditions and other brain tumors. Cytokines and chemokines in cerebrospinal fluid (CSF) have shown potential as biomarkers for PCNSL, but the conclusion on their diagnostic utility is unavailable. This study intended to assess the role of CSF cytokines and chemokines in differentiating PCNSL from other CNS disorders.

Methods

We searched electronic databases extensively to find studies that examined the sensitivity and

SUBMITTER: Singh S 

PROVIDER: S-EPMC12798882 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature