Expression of the biofilm-associated protein interferes with host protein receptors of Staphylococcus aureus and alters the infective process.

ABSTRACT: The adherence of Staphylococcus aureus to soluble proteins and extracellular-matrix components of the host is one of the key steps in the pathogenesis of staphylococcal infections. S. aureus presents a family of adhesins called MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) that specifically recognize host matrix components. We examined the influence of biofilm-associated protein (Bap) expression on S. aureus adherence to host proteins, epithelial cell cultures, and mammary gland sections and on colonization of the mammary gland in an in vivo infection model. Bap-positive strain V329 showed lower adherence to immobilized fibrinogen and fibronectin than isogenic Bap-deficient strain m556. Bacterial adherence to histological sections of mammary gland and bacter

SUBMITTER: Cucarella C 

PROVIDER: S-EPMC127991 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature