Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.

ABSTRACT: Presynaptic inhibition after spinal cord injury (SCI) has been hypothesised to disproportionately affect flexion reflex loops in locomotor spinal circuitry. Reducing gamma-aminobutyric acid (GABA) inhibitory activity increases the excitation of flexion circuits, restoring muscle activation and stepping ability. Conversely, nociceptive sensitisation and muscular spasticity can emerge from insufficient GABAergic inhibition. To investigate the effects of neuromodulation and proprioceptive sensory afferents in the spinal cord, a biologically constrained spiking neural network (SNN) was developed. The network describes the ankle flexor motoneuron (MN) reflex loop with inputs from ipsilateral Ia- and II-fibres and tonically firing interneurons. The model was tuned to a Baseline level of locomoti

SUBMITTER: Chia R 

PROVIDER: S-EPMC12799191 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature