¹¹C-Hydroxyephedrine PET/CT for preoperative surgical planning in large pheochromocytoma and paraganglioma.

ABSTRACT: Early detection of metastases and timely surgical intervention play a crucial role in the management of neuroendocrine tumors. In large-sized pheochromocytomas and sympathetic paragangliomas (PPGL), functional imaging with positron emission tomography (PET) is recommended, as it improves the detection of metastases, which may go undetected on conventional radiologic imaging. ¹¹C-hydroxyephedrine binds to the norepinephrine transporter receptor and is detected by PET/CT (HED-PET/CT). It has previously demonstrated high accuracy in detecting primary and metastatic PPGL; however, its impact on preoperative staging is unclear. In this study, we retrospectively analyzed a selected cohort of 44 patients with large PPGL to evaluate whether HED-PET/CT influences preoperative clinical de

SUBMITTER: Vyakaranam AR 

PROVIDER: S-EPMC12799324 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature