Multifactorial Biomarkers for "Talk and Deteriorate" after Head Trauma Identified Using Machine Learning.

ABSTRACT: Talk and Deteriorate refers to a clinical course where a patient is able to speak immediately after a traumatic brain injury but subsequently deteriorates in consciousness. Talk and Deteriorate outcomes are poor, and reliable prediction may help improve them. We searched for multifactorial biomarkers-combinations of multiple risk factors-assuming they would predict Talk and Deteriorate more reliably than single factors. A total of 680 consecutive patients aged ≥16 years with intracranial traumatic lesions and a Glasgow Coma Scale of 13-15 upon admission were included. Information on 27 factors at admission and whether Talk and Deteriorate developed was collected. The correlation between Talk and Deteriorate incidence and each factor was evaluated using univariate analysis. Multifactorial b

SUBMITTER: Takeuchi Y 

PROVIDER: S-EPMC12799341 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature