High concentrations of polyunsaturated n-3 fatty acids in serum are inversely associated with risk of future incident venous thromboembolism - the HUNT cohort study.

ABSTRACT:

Background

Previous studies on the association between n-3 (ω-3) polyunsaturated fatty acids (n-3 PUFAs) and risk of venous thromboembolism (VTE), mainly derived from self-reported dietary intake of n-3 PUFAs, have shown mixed results.

Objectives

The aim of this cohort study was to investigate the association between measured serum n-3 PUFA concentrations and risk of first-ever VTE.

Methods

The present cohort (N = 17,087) was derived from the third survey of the Trøndelag Health Study and consisted of individuals aged ≥20 y without previous VTE. Serum n-3 PUFA concentrations were measured in blood drawn at inclusion (2006-2008) using a nuclear magnetic resonance metabolomic platform (Nightingale), and participants were followed until an objectively verified first-ever

SUBMITTER: Johansson M 

PROVIDER: S-EPMC12799366 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature