Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study.

ABSTRACT:

Background

Although the Mediterranean (MED) diet has been associated with reduced rheumatoid arthritis (RA) risk, the underlying metabolic mechanisms and the role of genetic susceptibility in this relationship remain unknown.

Objectives

This study aims to identify a metabolic signature linked to the MED diet and examine its association with the risk of RA, while accounting for genetic predispositions.

Methods

We analyzed data from 109,565 participants in the UK Biobank. Elastic net regression was applied to generate a MED-related metabolic signature. Cox proportional hazards models were used to assess the associations among MED diet score, its derived metabolic signature, and incident RA. A polygenic risk score for RA was incorporated to evaluate joint associations an

SUBMITTER: Song X 

PROVIDER: S-EPMC12799371 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature