Impact of comprehensive lifestyle interventions on plasma branched-chain amino acid concentrations: a randomized trial.

ABSTRACT:

Background

Elevated plasma branched-chain amino acid (BCAA) concentrations are associated with a higher risk of type 2 diabetes and cardiovascular diseases. Lifestyle interventions have been proposed as a strategy to manage plasma BCAA concentrations, but evidence of their effectiveness is limited.

Objectives

We investigated the effects of comprehensive lifestyle interventions on plasma BCAA concentrations over 6 mo and associations between changes in body mass index (BMI), physical fitness, and dietary factors and plasma BCAA changes.

Methods

The PREMIER study was a randomized trial of the effects of behavioral lifestyle interventions. The interventions included counseling on diet, exercise, and weight loss ("Established"), a similar intervention with additional guid

SUBMITTER: Lim YJ 

PROVIDER: S-EPMC12799384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature