Dietary Fat Intake Attenuates Vitamin A Deficiency-Associated Elastic Fiber Remodeling and Lipid Reduction in the Alveolar Niche in Mice.

ABSTRACT:

Background

Vitamin A deficiency (VAD) and obesity are widespread nutrition-related health conditions that are independently associated with pulmonary remodeling processes linked to lung function decline and respiratory diseases.

Objectives

This study tested the hypothesis that VAD-related pulmonary alterations are aggravated by diet-induced obesity.

Methods

Eight-week-old C57BL/6J/129Sv mice with a deletion of lecithin-retinol-acyltransferase (Lrat-; impaired vitamin A storage) were fed vitamin A deficient control diet (CD, n = 13) or high-fat diet (HFD, n = 15) to induce VAD in lean (CD-VAD, n = 13) or obese (HFD-VAD, n = 13) mice. Wild-type mice receiving vitamin A-containing CD or HFD served as controls. After 20 wk, lungs were subjected to structural and molecular

SUBMITTER: Hoy LM 

PROVIDER: S-EPMC12799404 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature