Associations of Serum n-6 Polyunsaturated Fatty Acid Concentrations with Heart Rate-Corrected QT and JT Intervals in Middle-Aged Males.

ABSTRACT:

Background

Although n-6 (ω-6) polyunsaturated fatty acids (PUFAs), particularly the main n-6 PUFA linoleic acid (LA), have been shown to be inversely related to cardiovascular disease (CVD) risk, their associations with ventricular repolarization, a marker of ventricular arrhythmias, remain unclear.

Objectives

This study examined the relationships between serum n-6 PUFA concentrations and heart rate-corrected QT (QTc) and JT (JTc) intervals.

Methods

This cross-sectional study included 1420 Finnish males (aged 42-60 y) free of CVD from the Kuopio Ischaemic Heart Disease Risk Factor Study. Fasting serum n-6 PUFA concentrations were determined by gas chromatography, and electrocardiographic intervals were automatically derived. QTc and JTc intervals were calculated using

SUBMITTER: Esmaili H 

PROVIDER: S-EPMC12799411 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature