The Association of Gut Microbiota With TRPM7 Genotype, Colorectal Polyps, and Magnesium.

ABSTRACT:

Background

We previously reported that individuals with the transient receptor potential melastatin 7 (TRPM7) GA/AA genotype and consumed diets high in Ca:Mg ratio had increased risk of colorectal polyps.

Objectives

The aim was to identify whether the gut microbiota plays a role in the association of TRPM7 genotype, Ca:Mg intake ratio, and risk of colorectal polyps.

Methods

We analyzed the gut microbiota of 240 participants in a double-blind 2 × 2 factorial (TRPM7 genotype and Ca:Mg intake ratios) randomized trial by sequencing the stool, rectal swab, and rectal mucosa tissue samples of each participant.

Results

The gut microbiota of participants with the GA genotype significantly differed from those with the GG genotype in all 3 sample types, with an altered a

SUBMITTER: Sun S 

PROVIDER: S-EPMC12799418 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature