Restrictive versus liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomised controlled trial.

ABSTRACT:

Background

Maintaining adequate oxygen delivery during cardiopulmonary bypass (CPB)-assisted cardiac surgery is crucial, but hyperoxia has been suggested to cause organ injury. We compared the effects of restrictive vs liberal oxygenation during CPB and weaning from CPB on clinical outcomes in cardiac surgery.

Methods

We conducted a single-centre, patient- and assessor-blinded randomised trial on adults undergoing CPB-assisted coronary artery bypass grafting, aortic valve replacement, or both. Participants were randomly assigned (1:1) to restrictive (Fio₂=50%) or liberal (Fio₂=100%) oxygen therapy during and for the first hour after weaning from CPB. The primary composite outcome was the time to death, stroke, renal failure requiring dialysis, or new-on

SUBMITTER: Wiberg S 

PROVIDER: S-EPMC12799424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature