Vitamin C status across the spectrum of chronic kidney disease and healthy controls: a cross-sectional study.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) are at risk for vitamin C (VitC) deficiency.

Objectives

We aimed to investigate VitC status and its determinants across the spectrum of CKD and healthy individuals.

Methods

In this cross-sectional study, we measured plasma VitC concentrations (<10 μmol/L = deficient, 10‒35 μmol/L = inadequate) in 62 individuals on dialysis, 41 with CKD stage 4/5, 42 kidney transplant recipients (KTRs) (together: CKD population), and in 447 living kidney donors, and 385 healthy controls (together: healthy population). In the CKD population, we assessed VitC intake (<75 mg/d = inadequate) using 24-h dietary recalls. We measured VitC removal by hemodialysis. We investigated potential determinants of plasma VitC with linear regression

SUBMITTER: Doorenbos CSE 

PROVIDER: S-EPMC12799429 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature