Sequential Meals Containing Animal and Plant-Based Saturated Fats Have Differential Effects on Postprandial Gut Hormones but No Impact on Satiety Compared with Unsaturated Fats in Generally Healthy Males: Findings from the Randomized Controlled Crossover CocoHeart Study.

ABSTRACT:

Background

Saturated fat (SFA)-rich meals are often linked to elevated postprandial triacylglycerol responses compared with unsaturated fats. Despite the growing popularity of coconut oil in the United Kingdom diet, effects of this SFA-rich oil on postprandial lipemia and physiological appetite responses are unclear.

Objectives

This study compared sequential high-fat test meals rich in butter and coconut oil with a vegetable oil blend (safflower and olive oil) on postprandial triacylglycerol (primary outcome), lipids, glucose, and gut hormones responses, and physiological measures of appetite in healthy males.

Methods

In a single-blind, randomized acute 3-armed crossover study, 13 males (53 ± 3 years, body mass index 24.4 ± 3.0 kg/m²) consumed sequential te

SUBMITTER: Wong G 

PROVIDER: S-EPMC12799432 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature