Microbiota-Dependent Fiber Responses: A Proof-of-Concept Study on Short-Chain Fatty Acid Production in Prevotella- and Bacteroides-Dominated Healthy Individuals.

ABSTRACT:

Background

Dietary fiber supports metabolic health via microbial fermentation, producing short-chain fatty acids (SCFAs). However, metabolic responses to fiber vary between individuals, potentially due to differences in gut microbiota composition. The Prevotella-to-Bacteroides ratio has emerged as a potential biomarker for fiber responsiveness.

Objectives

This study examined how stratified fiber supplementation affects microbial and metabolic outcomes in individuals with Prevotella (P-type)- or Bacteroides-dominated (B-type) microbiota.

Methods

In this single-blinded, randomized crossover study, 23 healthy adults were classified as P-type (≥10% Prevotella) or B-type (≥10% Bacteroides) via 16S rRNA sequencing. Participants consumed 15 g/d of arabinoxylan (AX), inulin (

SUBMITTER: Bartsch M 

PROVIDER: S-EPMC12799433 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature