Effect of neuromuscular blocking agents on tracheal intubation quality in paediatric patients: a systematic review using network meta-analysis and meta-regression.

ABSTRACT:

Background

This meta-analysis is the first to compare tracheal intubation conditions and haemodynamic responses produced by various types and doses of neuromuscular blocking agents (NMBAs) in paediatric anaesthesia while also exploring factors associated with variability in outcomes.

Methods

Randomised controlled and controlled clinical trials involving healthy paediatric participants (0-12 yr) were included. Trials compared intubation conditions using various NMBA interventions or NMBA-free settings under direct laryngoscopy. Outcomes included odds ratios (ORs) for excellent and acceptable intubation conditions, and mean differences for MAP and HR. Bayesian network, pairwise, and cumulative meta-analyses, along with meta-regression, assessed NMBA effectiveness and covariate

SUBMITTER: Vanlinthout LE 

PROVIDER: S-EPMC12799451 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature