Vitamin B-6 Deficiency Induces Anxiety-Like Behavior in Sprague-Dawley Rats by Disrupting Gut Homeostasis.

ABSTRACT:

Background

Vitamin B-6 (VB-6) is essential for numerous metabolic pathways, including neurotransmitter synthesis, and its deficiency has been linked to neurologic disorders. Emerging evidence suggests that B vitamin deficiencies can disturb the gut microbiome. Although the gut-brain axis is well recognized, the influence of VB-6 deficiency on behavior via gut-mediated mechanisms remains poorly understood.

Objectives

This study aimed to investigate the role of VB-6 in modulating the gut-brain axis and its impact on neurobehavioral outcomes.

Methods

Sixty-four Sprague-Dawley rats were fed an AIN-93G-based diet with either optimal [optimum vitamin B-6 (OB-6)] or deficient [deficient vitamin B-6 (DB-6)] amounts of VB-6 for 7 wk. Half of the rats received antibiotics in dr

SUBMITTER: Amarasena S 

PROVIDER: S-EPMC12799459 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature