Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort.

ABSTRACT:

Background

The global prevalence of obesity, an established risk and progression factor for colon cancer, is high and rising. Unfortunately, the mechanisms underlying the obesity-colon cancer association are incompletely understood, and new molecular targets enabling more effective intervention strategies to break the obesity-colon cancer link are urgently needed.

Objectives

This study integrated RNA sequencing data from mouse and human colon tumor samples, as well as human adipose samples, to rigorously establish obesity-associated transcriptomic signatures conserved between the 2 species.

Methods

We employed a mouse colon cancer model with colonoscopy-guided orthotopic transplantation of syngeneic Apc^nullKras^G12D/+Trp53^nullSmad4

SUBMITTER: Glenny EM 

PROVIDER: S-EPMC12799463 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature