LOXL2 alleviates post-traumatic knee osteoarthritis and pain.

ABSTRACT:

Background

Cartilage has limited potential for self-regeneration, and damage results in structural, molecular, and functional aberrations, leading to osteoarthritis (OA). Traumatic knee injuries can also lead to cartilage degeneration and post-traumatic OA (PTOA). This study aimed to explore whether lysyl oxidase-like 2 (LOXL2) deletion aggravate PTOA and overexpression alleviate inflammation and pain at mechanical as well as molecular levels.

Methods

Modified medial meniscectomy was performed on C57BL/6J mice knee followed by aggrecan promotes specific deletion of Loxl2 in cartilage. Transcriptomic aberrations were studied using RNA-seq and qPCR, and biomechanics and allodynia was evaluated using treadmill exhaustion and von Frey nociception test after adenovirus-del

SUBMITTER: Ali F 

PROVIDER: S-EPMC12799509 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature