Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and I_Ks by UCL2077.

ABSTRACT: In cardiomyocytes, Kv7.1 associates with the regulatory subunit KCNE1 to generate the delayed rectifier potassium current I_Ks, which plays a crucial role in cardiac repolarization at elevated heart rates. Gain-of-function mutations in either of these subunits are associated with short QT syndrome, a condition that increases the risk of cardiac arrhythmias including atrial fibrillation, syncope, and sudden death. Therefore, the study of pharmacological inhibitors of Kv7.1 and I_Ks is of significant therapeutic interest. In this work, we used whole-cell patch clamp recordings to characterize the electrophysiological effects of the Kv7.1 blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077) in both Kv7.1 and I_Ks (Kv7.1 + KCNE1) channels. We found that UCL207

SUBMITTER: Sastre D 

PROVIDER: S-EPMC12799529 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature