A Pooled Analysis of Sex Differences in Lupus Nephritis.

ABSTRACT:

Introduction

Lupus nephritis (LN) has been reported to be more severe and have worse outcomes in males than females. To determine if sex differences exist in disease severity at diagnosis or relapse, first treatment choice, response to initial treatment, and key kidney and patient outcomes, we performed a pooled analysis of data from 4 randomized controlled trials (RCTs) and 7 cohort studies of LN.

Methods

The study population included an international representation of 831 females and 122 males with LN with a median follow-up of 41.4 months. Baseline characteristics and outcomes (complete renal response [CRR], doubling of creatinine (Cr), dialysis, death, LN relapse, or composite outcomes) were compared between sexes using the entire data set. Cohort data were used to analy

SUBMITTER: Nasr KK 

PROVIDER: S-EPMC12799560 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature