Biomarker Prediction of Delayed Graft Function and Prognosis Post-Kidney Transplantation.

ABSTRACT:

Introduction

Aminoacylase-1 (ACY1) and additional biomarkers were evaluated for prediction of delayed graft function (DGF) and prognosis following kidney transplantation.

Methods

Serum biomarkers were measured (days 1-2 posttransplant for DGF prediction and 1-3 for prognosis) in 237 patients transplanted in Leeds (2003-2011) in the discovery phase, and 319 patients from 7 UK transplant centers (2012-2016) in the validation phase. Median follow-up was 13.28 years (interquartile range [IQR]: 12.4-13.8) and 9.03 years (IQR: 5.19-10.16), respectively.

Results

DGF occurred in 29.5% of discovery cohort patients and 18.2% of validation cohort patients. A DGF linear predictor combining ACY1, soluble tumor necrosis factor receptor-1 (sTNFR1) and cystatin C (CysC) demonstrated

SUBMITTER: Banks RE 

PROVIDER: S-EPMC12799578 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature