Transient receptor potential vanilloid 3 activation accelerates keratinocyte migration in vitro but not dermal wound healing in vivo.

ABSTRACT: The non-selective Ca²⁺ permeable transient receptor potential vanilloid 3 (TRPV3) ion channel is highly expressed in mouse keratinocytes, where its activation causes an accelerated cell migration and proliferation via an epidermal growth factor receptor-mediated mechanism in vitro. Therefore, TRPV3 has been proposed as a potential target to accelerate dermal wound healing. In this study, we provide an insight into the effects of TRPV3 activation on mouse keratinocytes and skin wound healing in vitro and in vivo using the newly identified activator of TRPV3 1 (AV3-1). To investigate a possible TRPV3-mediated effect on dermal wound closure in vivo, 2 circular wounds were excised on the back of wild-type and TRPV3 knockout mice and topically treated with AV3-1 or the corresponding

SUBMITTER: Zosel C 

PROVIDER: S-EPMC12799580 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature