Povetacicept for IgA Nephropathy and Primary Membranous Nephropathy.

ABSTRACT:

Introduction

Povetacicept is an inhibitor of B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL), 2 cytokines central to the pathogenesis of autoimmune glomerulonephritis. Both BAFF and APRIL promote B-cell and plasma cell survival and function. APRIL primarily supports plasma cell survival and function, whereas BAFF regulates early pathogenic B-cell development, activates pathogenic T cells and innate immune cells, and contributes to mesangial cell proliferation and podocyte injury.

Methods

Our phase 1 and 2, open-label study evaluated povetacicept in adult participants with IgA nephropathy (IgAN) or primary membranous nephropathy (pMN), all with estimated glomerular filtration rate (eGFR) of ≥ 30 ml/min per 1.73 m². The primary objective

SUBMITTER: Madan A 

PROVIDER: S-EPMC12799581 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature