Comparison of viscoelastic properties of breast cancer and normal cells using AFM, FLIM and ToF-SIMS techniques.

ABSTRACT: The modifications in biomechanical properties of cells and tissue are important in cancer progression, including its different aspects, e.g. invasion, migration, adhesion, signaling, interactions with microenvironment, and immune response. However, our understanding of the changes in physical characteristics of cells, and especially the molecular basis for these changes, caused by malignant transformation remains rather limited. While the differences in stiffness and viscoelasticity of tumor and normal cells have been well documented at the cellular scale, subcellular and molecular alterations have been poorly characterised. In our work, we investigated the stiffness and viscoelastic parameters, mainly determined by the actin cortex, and the microviscosity of the plasma membrane, mainly de

SUBMITTER: Shimolina L 

PROVIDER: S-EPMC12799608 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature